Reducing chronic inflammation for healthier aging.
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Inflammation and Joint Health
Key Points:
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Long considered "wear and tear," research shows inflammation plays a massive role in breaking down joint cartilage.
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Prevalence of OA has skyrocketed (up by over 130% since 1990) due to aging populations and rising obesity rates.
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Musculoskeletal conditions (including inflammatory joint disease) rank second globally for years lived with disability.
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Joint inflammation disproportionately affects women (who account for roughly 60% of OA cases and 70% of RA cases) and older adults.
Dig Deeper: The Science
How Inflammation Affects
the Joints
Inflammation affects joints by triggering immune cells to rush to the area, leading to swelling of the joint lining (synovium). This response increases blood flow and fluid buildup, creating internal pressure and leading to pain, stiffness, warmth, and reduced mobility.
Chronic inflammation is particularly destructive to joints because it triggers a continuous release of inflammatory chemicals. Over time, this process leads to several major issues within the joint structure. Cartilage destruction occurs when the smooth cartilage that protects the ends of bones breaks down, allowing the bones to rub directly against each other. Continued inflammation can erode the bone itself, leading to structural changes and deformities. As the joint capsule stretches, the muscles, ligaments, and tendons that stabilize the joint become weak and less functional.